Acyclovir Ophthalmic

Name: Acyclovir Ophthalmic Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 535 cited references

Also sold as: Avaclyr Avaclyr® Sitavig Zovirax

About Acyclovir Ophthalmic

Ophthalmic acyclovir is used to treat an infection of the eye caused by herpes simplex virus. Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the eye. Read the full Acyclovir Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bupropion Clomipramine Dichlorphenamide Emtricitabine Fexinidazole

1 Contraindicated 17 Major 5 Moderate 1 Minor

All (24) Contraindicated (1) Major (17) Moderate (5) Minor (1)

Minor

Acyclovir Ophthalmic Zidovudine Retrovir Increased lethargy and fatigue Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.