Acyclovir Ophthalmic

Name: Acyclovir Ophthalmic Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 535 cited references

Also sold as: Avaclyr Avaclyr® Sitavig Zovirax

About Acyclovir Ophthalmic

Ophthalmic acyclovir is used to treat an infection of the eye caused by herpes simplex virus. Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the eye. Read the full Acyclovir Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bupropion Clomipramine Dichlorphenamide Emtricitabine Fexinidazole

1 Contraindicated 17 Major 5 Moderate 1 Minor

All (24) Contraindicated (1) Major (17) Moderate (5) Minor (1)

Moderate

Acyclovir Ophthalmic Fosphenytoin Cerebyx Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Ophthalmic Meperidine Demerol Increased meperidine and its metabolite normeperidine exposure Details Acyclovir Ophthalmic Phenytoin Dilantin Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Ophthalmic Probenecid Increased OAT3 substrate exposure Details Acyclovir Ophthalmic Valproic Acid Depakene® Decreased valproic acid plasma concentrations and potential increased seizure activity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.