Acyclovir Topical
24 interactions 535 cited referencesAcyclovir cream is used to treat cold sores (fever blisters; blisters that are caused by a virus called herpes simplex) on the face or lips. Acyclovir ointment is used to treat first outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time) and to… Read the full Acyclovir Topical drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Acyclovir Topical Bupropion Aplenzin Increased risk of seizures Details Acyclovir Topical Clomipramine Anafranil Increased clomiPRAMINE exposure and an increased risk of seizures Details Acyclovir Topical Dichlorphenamide Increased OAT1 substrate exposure Details Acyclovir Topical Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Acyclovir Topical Fexinidazole Increased exposure of OAT1/OAT3 substrate Details Acyclovir Topical Foscarnet Foscavir Nephrotoxicity Details Acyclovir Topical Hydroxychloroquine Plaquenil An increased risk of seizures Details Acyclovir Topical Leflunomide Arava Increased exposure of OAT3 substrate Details Acyclovir Topical Mycophenolate Mofetil Increased acyclovir exposure and an increased risk of acyclovir-related adverse reactions Details Acyclovir Topical Nitisinone Increased OAT1 or OAT3 substrate exposure and an increased risk of OAT1 or OAT3 substrate-related adverse effects Details Acyclovir Topical Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Acyclovir Topical Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Acyclovir Topical Teriflunomide Aubagio Increased exposure of OAT3 substrate Details Acyclovir Topical Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Acyclovir Topical Tramadol ConZip An increased risk of seizure Details Acyclovir Topical Vadadustat Vafseo Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Acyclovir Topical Warfarin Coumadin Increased warfarin exposure and an increased INR DetailsModerate
Acyclovir Topical Fosphenytoin Cerebyx Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Topical Meperidine Demerol Increased meperidine and its metabolite normeperidine exposure Details Acyclovir Topical Phenytoin Dilantin Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Topical Probenecid Increased OAT3 substrate exposure Details Acyclovir Topical Valproic Acid Depakene® Decreased valproic acid plasma concentrations and potential increased seizure activity DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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