Acyclovir Topical

Name: Acyclovir Topical Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 535 cited references

Also sold as: Zovirax Zovirax® Cream Zovirax® Ointment

About Acyclovir Topical

Acyclovir cream is used to treat cold sores (fever blisters; blisters that are caused by a virus called herpes simplex) on the face or lips. Acyclovir ointment is used to treat first outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time) and to… Read the full Acyclovir Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bupropion Clomipramine Dichlorphenamide Emtricitabine Fexinidazole

1 Contraindicated 17 Major 5 Moderate 1 Minor

All (24) Contraindicated (1) Major (17) Moderate (5) Minor (1)

Moderate

Acyclovir Topical Fosphenytoin Cerebyx Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Topical Meperidine Demerol Increased meperidine and its metabolite normeperidine exposure Details Acyclovir Topical Phenytoin Dilantin Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Topical Probenecid Increased OAT3 substrate exposure Details Acyclovir Topical Valproic Acid Depakene® Decreased valproic acid plasma concentrations and potential increased seizure activity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.