Alpelisib

87 interactions 52 cited references

Also sold as: Piqray Piqray® Vijoice Vijoice®

About Alpelisib

Alpelisib (Piqray) is used in combination with fulvestrant (Faslodex) to treat a certain type of breast cancer that has spread to nearby tissues or other parts of the body in women who have already gone through menopause (''change of life,'' end of menstrual periods) or in men, whose cancer got worse during or after ce… Read the full Alpelisib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Ensitrelvir Bacillus Of Calmette And Guerin Vaccine, Live Dengue Tetravalent Vaccine, Live

10 Contraindicated 72 Major 5 Moderate

All (87) Contraindicated (10) Major (72) Moderate (5)

Contraindicated

Alpelisib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Ensitrelvir Increased CYP3A/BCRP substrate exposure and an increased risk of adverse reactions Details Alpelisib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Alpelisib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Alpelisib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Alpelisib Adagrasib Krazati Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Alpelisib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Alpelisib Apalutamide Erleada Reduced alpelisib exposure and reduced efficacy of alpelisib Details Alpelisib Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Alpelisib Capmatinib Tabrecta Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Carbamazepine Carbatrol Reduced alpelisib exposure and reduced efficacy of alpelisib Details Alpelisib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Alpelisib Cobicistat Tybost Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Curcumin Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Cyclosporine Atopica Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Daclatasvir Daklinza® Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Darolutamide Nubeqa Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Dasabuvir Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Elacestrant Orserdu Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Elbasvir Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Eltrombopag Alvaiz Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Enasidenib Idhifa Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Encorafenib Braftovi Altered alpelisib exposure, an increased risk of alpelisib-related adverse effects and toxicity and reduced efficacy of alpelisib Details Alpelisib Enzalutamide Xtandi Reduced alpelisib exposure and reduced efficacy of alpelisib Details Alpelisib Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Alpelisib Febuxostat Uloric Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Fosphenytoin Cerebyx Reduced alpelisib exposure and reduced efficacy of alpelisib Details Alpelisib Fostamatinib Tavalisse Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Fostemsavir Rukobia Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Glecaprevir Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Grazoprevir Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Alpelisib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Alpelisib Itraconazole Sporanox Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details

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