Alpelisib

Name: Alpelisib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

87 interactions 52 cited references

Also sold as: Piqray Piqray® Vijoice Vijoice®

About Alpelisib

Alpelisib (Piqray) is used in combination with fulvestrant (Faslodex) to treat a certain type of breast cancer that has spread to nearby tissues or other parts of the body in women who have already gone through menopause (''change of life,'' end of menstrual periods) or in men, whose cancer got worse during or after ce… Read the full Alpelisib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Ensitrelvir Bacillus Of Calmette And Guerin Vaccine, Live Dengue Tetravalent Vaccine, Live

10 Contraindicated 72 Major 5 Moderate

All (87) Contraindicated (10) Major (72) Moderate (5)

Moderate

Alpelisib Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Alpelisib Kratom Increased CYP3A substrate exposure Details Alpelisib Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Alpelisib Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Alpelisib Zongertinib Hernexeos Increased BCRP substrates exposure and an increased risk of BCRP substrates-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.