Amiodarone

141 interactions 9 explained in plain English
Also sold as: Nexterone Pacerone
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Amiodarone Dolasetron Injection Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Amiodarone Edoxaban Savaysa Increased edoxaban exposure Details Amiodarone Encorafenib Braftovi Increased risk of QT interval prolongation Details Amiodarone Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Amiodarone Erdafitinib Balversa Increased erdafitinib exposure Details Amiodarone Eribulin Injection Halaven An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Erlotinib Tarceva Neurotoxicity Details Amiodarone Famotidine Calmicid An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Famotidine Injection Calmicid An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Felbamate Felbatol An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Fentanyl Transdermal Patch Duragesic® Cardiac toxicity (low cardiac output) and an increased risk of fentanyl toxicity (CNS depression, respiratory depression) Details Amiodarone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Amiodarone Flecainide Tambocor® Increased antiarrhythmic levels, QTc prolongation Details Amiodarone Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Fostemsavir Rukobia Increased risk of torsade de pointes Details Amiodarone Galantamine Razadyne An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Gemfibrozil Lopid Increased amiodarone exposure Details Amiodarone Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Glasdegib Daurismo Increased risk of QT interval prolongation Details Amiodarone Goserelin Implant Zoladex Increased risk of QT prolongation Details Amiodarone Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Granisetron Injection Granisol An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Histrelin Implant Supprelin Increased risk of QT prolongation Details Amiodarone Hydroxychloroquine Plaquenil An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Amiodarone Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Ivabradine Corlanor An increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Amiodarone Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and an increased risk of QT interval prolon... Details Amiodarone Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Amiodarone Letermovir Injection Prevymis Increased amiodarone exposure Details Amiodarone Levofloxacin Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Levofloxacin Injection Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amiodarone Loperamide Diamode Increased loperamide exposure, an increased risk of loperamide-related adverse effects, an increased risk of QT interval prolongat... Details Amiodarone Loratadine Agistam® Increased risk of QT interval prolongation and torsade de pointes Details Amiodarone Lovastatin Altocor® Increased lovastatin exposure and an increased risk myopathy and rhabdomyolysis Details Amiodarone Macitentan Opsumit Increased macitentan exposure Details Amiodarone Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.