Amiodarone

141 interactions 9 explained in plain English

Also sold as: Nexterone Pacerone

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Deuruxolitinib Colchicine Glasdegib Galantamine Miconazole Vaginal

3 Contraindicated 111 Major 26 Moderate 1 Minor

All (141) Contraindicated (3) Major (111) Moderate (26) Minor (1)

Moderate

Amiodarone Apixaban Eliquis Explained Increased apixaban exposure and increased risk of bleeding Details Amiodarone Atorvastatin Atorvaliq An increased risk of myopathy or rhabdomyolysis Details Amiodarone Cyclosporine Injection Atopica Increased plasma levels of cycloSPORINE Details Amiodarone Cyclosporine Ophthalmic Cequa Increased plasma levels of cycloSPORINE Details Amiodarone Diclofenac Ophthalmic Voltaren® Eye Drops Increased exposure of diclofenac Details Amiodarone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased exposure of diclofenac Details Amiodarone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased exposure of diclofenac Details Amiodarone Diclofenac Transdermal Patch Flector Increased exposure of diclofenac Details Amiodarone Estradiol Delestrogen Increased hormonal contraceptive exposure Details Amiodarone Estradiol Topical Divigel Increased hormonal contraceptive exposure Details Amiodarone Estradiol Transdermal Patch Alora® Increased hormonal contraceptive exposure Details Amiodarone Fluvastatin Lescol Increased plasma levels of fluvastatin Details Amiodarone Glimepiride Amaryl Increased plasma levels of glimepiride Details Amiodarone Glipizide Glucotrol Increased plasma levels of glipiZIDE Details Amiodarone Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Amiodarone Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Amiodarone Ibrutinib Imbruvica Increased ibrutinib exposure and risk of atrial fibrillation Details Amiodarone Irbesartan Avapro Increased plasma levels of irbesartan Details Amiodarone Levonorgestrel After banger Increased hormonal contraceptive exposure Details Amiodarone Levonorgestrel Intrauterine System Kyleena Increased hormonal contraceptive exposure Details Amiodarone Levothyroxine Ermeza Decreased levothyroxine efficacy Details Amiodarone Losartan Arbli Increased plasma levels of losartan and decreased plasma levels of the active metabolite Details Amiodarone Naproxen Aleve Increased plasma levels of naproxen Details Amiodarone Nateglinide Starlix® Increased risk of hypoglycemia Details Amiodarone Nimodipine Nimotop Increased nimodipine serum levels Details Amiodarone Orlistat Alli Reduced amiodarone and its metabolite (desethylamiodarone) exposure and reduced efficacy of amiodarone Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.