Amitriptyline

525 interactions 416 explained in plain English 1,325 cited references

Also sold as: Elavil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Saquinavir Safinamide Procarbazine Potassium Citrate Potassium Chloride

35 Contraindicated 421 Major 55 Moderate 14 Minor

All (525) Contraindicated (35) Major (421) Moderate (55) Minor (14)

Major

Amitriptyline Ceritinib Zykadia Explained An increased risk of QT interval prolongation Details Amitriptyline Chloral Hydrate Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Chlorpheniramine Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Chlorpromazine Explained An increased risk of QT interval prolongation Details Amitriptyline Choline Salicylate Explained An increased risk of bleeding Details Amitriptyline Ciprofloxacin Explained An increased risk of QT interval prolongation and torsade de pointes Details Amitriptyline Citalopram Celexa Explained An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Amitriptyline Clarithromycin Biaxin Explained Increased risk of QT interval prolongation Details Amitriptyline Clofazimine Explained An increased risk of QT interval prolongation Details Amitriptyline Clomipramine Anafranil Explained An increased risk of QT interval prolongation, an increased risk of anticholinergic effects and an increased risk of serotonin syn... Details Amitriptyline Clonidine Duraclon Explained Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Amitriptyline Clonixin Explained An increased risk of bleeding Details Amitriptyline Clothiapine Explained Increased risk of cardiac arrhythmias Details Amitriptyline Clozapine Clozaril Explained An increased risk of anticholinergic toxicity, gastrointestinal adverse reactions, and an increased risk of QT interval prolongati... Details Amitriptyline Cobicistat Tybost Explained Increased exposure of amitriptyline Details Amitriptyline Cocaine Goprelto Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Amitriptyline Crizotinib Xalkori Explained An increased risk of QT interval prolongation Details Amitriptyline Cyclobenzaprine Amrix Explained An increased risk of atropine-like adverse reactions, an increased risk of serotonin syndrome and an increased risk of QT interval... Details Amitriptyline Dabrafenib Tafinlar Explained An increased risk of QT interval prolongation Details Amitriptyline Darunavir Explained Increased tricyclic antidepressant/CYP2D6 substrate exposure Details Amitriptyline Dasatinib Phyrago An increased risk of QT interval prolongation Details Amitriptyline Degarelix Firmagon Explained Increased risk of QT interval prolongation Details Amitriptyline Delamanid Explained Increased risk of QT-interval prolongation Details Amitriptyline Desflurane Suprane Explained An increased risk of QT interval prolongation Details Amitriptyline Desipramine Norpramin Explained An increased risk of QT interval prolongation Details Amitriptyline Desvenlafaxine Pristiq Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonu... Details Amitriptyline Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Amitriptyline Dexibuprofen Explained An increased risk of bleeding Details Amitriptyline Dexketoprofen Explained An increased risk of bleeding Details Amitriptyline Dexmedetomidine Dexased Explained Increased risk of cardiac arrhythmias Details Amitriptyline Dextroamphetamine Dexedrine Explained An increased risk of serotonin syndrome Details Amitriptyline Dextromethorphan Delsym Explained Increased risk of serotonin syndrome Details Amitriptyline Diclofenac Aleve Arthritis Pain Explained An increased risk of bleeding Details Amitriptyline Diflunisal Dolobid Explained An increased risk of bleeding Details Amitriptyline Dihydrocodeine Explained Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Amitriptyline Dipyrone Explained An increased risk of bleeding Details Amitriptyline Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.