Amitriptyline

525 interactions 416 explained in plain English 1,325 cited references
Also sold as: Elavil
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Saquinavir Safinamide Procarbazine Potassium Citrate Potassium Chloride
35 Contraindicated 421 Major 55 Moderate 14 Minor
All (525) Contraindicated (35) Major (421) Moderate (55) Minor (14)

Moderate

Amitriptyline Abiraterone Acetate Abirtega Explained Increased exposure of amitriptyline Details Amitriptyline Abiraterone Acetate, Micronized Abirtega Explained Increased exposure of amitriptyline Details Amitriptyline Acenocoumarol Explained An increased risk of bleeding Details Amitriptyline Amprenavir Explained Increased tricyclic agent serum concentrations and potential toxicity (anticholinergic effects, sedation, confusion, cardiac arrhy... Details Amitriptyline Anisindione Explained An increased risk of bleeding Details Amitriptyline Arbutamine Explained Unreliable arbutamine test results Details Amitriptyline Arformoterol Brovana Explained An increased risk of cardiovascular excitation Details Amitriptyline Atomoxetine Atoncy Explained An increase in atomoxetine steady-state plasma concentrations Details Amitriptyline Belladonna Explained Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Amitriptyline Belladonna Alkaloids Explained Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Amitriptyline Bethanidine Explained Decreased antihypertensive effectiveness Details Amitriptyline Brimonidine Alphagan Explained Reduced brimonidine hypotensive effects Details Amitriptyline Cimetidine Tagamet Explained Amitriptyline toxicity (dry mouth, blurred vision, urinary retention) Details Amitriptyline Cinacalcet Explained Increased exposure of amitriptyline Details Amitriptyline Clobazam Onfi Explained Increased exposure of amitriptyline Details Amitriptyline Desmopressin DDAVP Explained Increased risk of water intoxication with hyponatremia Details Amitriptyline Desogestrel Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Diazepam Diastat Explained Psychomotor deficits (decreased reaction time, decreased vigilance) Details Amitriptyline Dicumarol Explained An increased risk of bleeding Details Amitriptyline Dienogest Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Diphenhydramine Banophen Explained Increased anticholinergic effects (dry mouth, urinary retention) Details Amitriptyline Disulfiram Antabuse An increased risk of a psychotic and confusional mental state Details Amitriptyline Drospirenone Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Ethinyl Estradiol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Ethynodiol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Fosamprenavir Lexiva Explained Increased tricyclic agent serum concentrations and potential toxicity (anticholinergic effects, sedation, confusion, cardiac arrhy... Details Amitriptyline Galantamine Razadyne Increased galantamine plasma concentrations Details Amitriptyline Gestodene Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Guanadrel Explained Decreased antihypertensive effectiveness Details Amitriptyline Guanethidine Explained Decreased antihypertensive effectiveness Details Amitriptyline Guanfacine Intuniv Decreased antihypertensive effectiveness Details Amitriptyline Levonorgestrel After banger Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Mestranol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Mirabegron Myrbetriq Explained Increased amitriptyline exposure Details Amitriptyline Nomegestrol Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Norethindrone Aygestin Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Norgestimate Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Norgestrel Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Amitriptyline Paltusotine Palsonify Explained An increased risk of PR interval prolongation Details Amitriptyline Phenindione Explained An increased risk of bleeding Details

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