Amitriptyline

525 interactions 416 explained in plain English 1,325 cited references

Also sold as: Elavil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Saquinavir Safinamide Procarbazine Potassium Citrate Potassium Chloride

35 Contraindicated 421 Major 55 Moderate 14 Minor

All (525) Contraindicated (35) Major (421) Moderate (55) Minor (14)

Major

Amitriptyline Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Amitriptyline Acecainide Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Aceclofenac Explained An increased risk of bleeding Details Amitriptyline Acemetacin Explained An increased risk of bleeding Details Amitriptyline Adagrasib Krazati Explained An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Amitriptyline Albuterol ProAir Explained An increased risk of cardiovascular system effects Details Amitriptyline Alfentanil Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Amitriptyline Alfuzosin UroXatral An increased risk of QT interval prolongation Details Amitriptyline Almotriptan Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Amantadine Explained Potentiation of anticholinergic effects Details Amitriptyline Amiodarone Nexterone Explained An increased risk of QT interval prolongation and torsade de pointes Details Amitriptyline Amisulpride Barhemsys Explained Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Amitriptyline Amobarbital Amytal Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Amitriptyline Amoxapine Explained An increased risk of QT interval prolongation Details Amitriptyline Amphetamine Dexedrine Explained An increased risk of serotonin syndrome Details Amitriptyline Amtolmetin Guacil Explained An increased risk of bleeding Details Amitriptyline Anagrelide Agrylin Increased risk of QT interval prolongation Details Amitriptyline Apomorphine Apokyn Explained An increased risk of QT interval prolongation Details Amitriptyline Aprindine Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Aprobarbital Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Amitriptyline Aripiprazole Abilify Explained An increased risk of QT interval prolongation Details Amitriptyline Aripiprazole Lauroxil Aristada Explained An increased risk of QT interval prolongation Details Amitriptyline Arsenic Trioxide Trisenox Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Artemether Explained An increased risk of QT interval prolongation Details Amitriptyline Asenapine Saphris Explained Increased risk of QT interval prolongation Details Amitriptyline Aspirin Acuprin® Explained An increased risk of bleeding Details Amitriptyline Astemizole Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Atazanavir Reyataz Explained Increased TCA exposure and an increased risk of QT interval prolongation Details Amitriptyline Azimilide Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Azithromycin AzaSite An increased risk of QT interval prolongation Details Amitriptyline Bedaquiline Sirturo Increased risk of QT interval prolongation Details Amitriptyline Benzhydrocodone Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of serotonin syndr... Details Amitriptyline Benzphetamine Explained An increased risk of serotonin syndrome Details Amitriptyline Bretylium Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Bromfenac Bromsite Explained An increased risk of bleeding Details Amitriptyline Brompheniramine Respa-BR Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Bufexamac Explained An increased risk of bleeding Details Amitriptyline Bupropion Aplenzin Explained Increased exposure of CYP2D6 substrates and an increased risk of seizure Details Amitriptyline Buspirone Bucapsol Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Butabarbital Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details

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