Amitriptyline

525 interactions 416 explained in plain English 1,325 cited references

Also sold as: Elavil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Saquinavir Safinamide Procarbazine Potassium Citrate Potassium Chloride

35 Contraindicated 421 Major 55 Moderate 14 Minor

All (525) Contraindicated (35) Major (421) Moderate (55) Minor (14)

Contraindicated

Amitriptyline Bepridil Explained An increased risk of QT interval prolongation Details Amitriptyline Bromopride Explained Increased risk of extrapyramidal reactions Details Amitriptyline Cisapride Propulsid® Explained Increased risk of QT interval prolongation Details Amitriptyline Clorgyline Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Dronedarone Multaq Explained Increased risk of QT interval prolongation Details Amitriptyline Furazolidone Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Grepafloxacin Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Iproniazid Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Isocarboxazid Marplan Explained An increased risk of hypertensive crisis, severe convulsive seizures, coma or circulatory collapse and an increased risk of seroto... Details Amitriptyline Levoketoconazole Recorlev Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Amitriptyline Levomethadyl Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amitriptyline Mavorixafor Xolremdi Explained Increased CYP2D6 substrate exposure, increased risk of CYP2D6-related adverse events and an increased risk of QT interval prolonga... Details Amitriptyline Mesoridazine Explained An increased risk of QT interval prolongation Details Amitriptyline Methylene Blue Provayblue Explained An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Amitriptyline Metoclopramide Explained An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Amitriptyline Moclobemide Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Nialamide Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Pargyline Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Phenelzine Nardil Explained An increased risk of CNS depression, an increased risk of neurotoxicity, seizures, and an increased risk of serotonin syndrome (hy... Details Amitriptyline Pimozide Explained An increased risk of QT interval prolongation Details Amitriptyline Piperaquine Explained Increased exposure of CYP2C19 substrates and increased risk of QT interval prolongation Details Amitriptyline Potassium Chloride K-Tab Explained Increased risk of gastrointestinal irritation Details Amitriptyline Potassium Citrate Urocit-K Explained Increased risk of gastrointestinal irritation Details Amitriptyline Procarbazine Explained Neurotoxicity, seizures Details Amitriptyline Safinamide Xadago Explained Increased risk of serotonin syndrome Details Amitriptyline Saquinavir Explained An increased risk of QT interval prolongation Details Amitriptyline Selegiline Anipryl Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Sparfloxacin Explained An increased risk of QT interval prolongation Details Amitriptyline Terfenadine Explained An increased risk of QT interval prolongation Details Amitriptyline Thioridazine Explained An increased risk of QT interval prolongation Details Amitriptyline Toloxatone Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Tranylcypromine Parnate Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Amitriptyline Ziprasidone Geodon Explained Increased risk of QT interval prolongation and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, men... Details Amitriptyline Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Amitriptyline Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

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