Amprenavir and Didanosine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amprenavir
No brand names on recordDidanosine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced amprenavir efficacy
Interaction Deep Dive
Amprenavir and didanosine coadministration has not been specifically studied. Didanosine chewable/dispersible tablets are buffered with calcium carbonate and magnesium hydroxide, and didanosine pediatric powder for oral solution is specifically reconstituted with an antacid preparation12. Based on data available between antacids and other protease inhibitors and the antacid content in didanosine, it is recommended that the administration of amprenavir and didanosine be separated by at least one hour 3.
Why it happens (mechanism)
Decreased amprenavir absorption
Common questions
Can I take Amprenavir and Didanosine together?
Reduced amprenavir efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amprenavir and Didanosine interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Amprenavir or Didanosine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Product Information: VIDEX EC(R) delayed release oral capsules, enteric coated beadlets, didanosine delayed release oral capsules, enteric coated beadlets. Bristol-Myers Squibb Company, Princeton, NJ, 2009.
- Product Information: VIDEX(R) pediatric powder for oral solution, didanosine pediatric powder for oral solution. Bristol-Myers Squibb Company, Princeton, NJ, 2009.
- Product Information: AGENRASE(R) oral capsules, amprenavir oral capsules. GlaxoSmithKline, Research Triangle Park, NC, 2005.
Keep reading about Amprenavir
Keep reading about Didanosine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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