Amprenavir and Dolutegravir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amprenavir
No brand names on recordDolutegravir
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced dolutegravir exposure and reduced efficacy of dolutegravir
Interaction Deep Dive
The coadministration of dolutegravir and fosamprenavir/ritonavir resulted in decreased dolutegravir AUC and Cmax in pharmacokinetic studies. Adjust the dolutegravir dose to 50 mg twice daily in treatment-naive or treatment-experienced, integrase strand transfer inhibitor (INSTI)-naive adults1 and in pediatric patients 25 kg or greater 2. In pediatrics weighing 10 to less than 25 kg, administer an additional weight-based dose of dolutegravir; (6 to less than 10 kg) 15 mg; (10 to less than 14 kg) 20 mg; (14 to less than 20 kg) 25 mg; (20 to less than 25 kg) 30 mg 3. Consider alternative combinations without metabolic inducers for patients who are INSTI-experienced with certain INSTI-associated resistance substitutions or have clinically suspected INSTI resistance 1. When administering the abacavir/dolutegravir/lamivudine combination product, separate the additional dolutegravir dose by 12 hours 2.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of dolutegravir by fosamprenavir/ritonavir
Literature reports
1 report — tap to read
a) In pharmacokinetic studies, the coadministration of dolutegravir 50 mg once daily and fosamprenavir 700 mg/ritonavir 100 mg twice daily resulted in significantly decreased dolutegravir exposure, with AUC decreasing by 35% and Cmax by 24% compared with dolutegravir alone 1.
Common questions
Can I take Amprenavir and Dolutegravir together?
Reduced dolutegravir exposure and reduced efficacy of dolutegravir Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amprenavir and Dolutegravir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Amprenavir or Dolutegravir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: TIVICAY oral tablets, dolutegravir oral tablets. ViiV Healthcare (per FDA), Research Triangle Park, NC, 2022. DailyMed
- Product Information: TRIUMEQ oral tablets, abacavir, dolutegravir, lamivudine oral tablets. ViiV Healthcare (per FDA), Durham, NC, 2023. DailyMed
- Product Information: TRIUMEQ PD oral tablets for suspension, abacavir, dolutegravir, lamivudine oral tablets. ViiV Healthcare (per FDA), Durham, NC, 2023. DailyMed
Keep reading about Amprenavir
Keep reading about Dolutegravir
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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