Anagrelide and Domperidone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Anagrelide
Domperidone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT interval prolongation
Interaction Deep Dive
Use caution with coadministration of anagrelide, a potential QT interval prolonging drug, and domperidone, a drug that has been associated with an increased risk of sudden cardiac death. In case control studies, an increased risk of sudden cardiac death was observed with the use of oral domperidone, particularly at doses greater than 30 mg/day and in patients older than 60 years. If coadministration is necessary, initiate domperidone at the lowest possible dose and titrate with caution. Discontinue domperidone if the patient experiences dizziness, palpitations, syncope, or seizure1.
Why it happens (mechanism)
Additive effects on the QT interval
Common questions
Can I take Anagrelide and Domperidone together?
Increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Anagrelide and Domperidone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Anagrelide or Domperidone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Teva Canada Limited: Dear Healthcare Professional letter for domperidone maleate. Teva Canada Limited. Toronto, Canada. 2012.
Keep reading about Anagrelide
Keep reading about Domperidone
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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