Domperidone

75 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Miconazole Vaginal Ofloxacin Otic Oxaliplatin Injection Octreotide Injection Relugolix
1 Contraindicated 74 Major
All (75) Contraindicated (1) Major (74)

Contraindicated

Domperidone Ketoconazole Topical Extina® Foam Increased domperidone exposure and increased risk of QT interval prolongation Details

Major

Domperidone Abametapir Explained Increased exposure of CYP3A4 substrate Details Domperidone Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Domperidone Sertraline Explained An increased risk of QT interval prolongation Details Domperidone Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Domperidone Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Domperidone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Domperidone Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Domperidone Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Domperidone Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Domperidone Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Domperidone Azithromycin AzaSite Increased risk of QT interval prolongation Details Domperidone Bicalutamide Casodex Increased domperidone exposure and an increased risk of QT prolongation Details Domperidone Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Domperidone Abiraterone Abirtega Increased domperidone exposure and an increased risk of QT interval prolongation Details Domperidone Alfuzosin UroXatral Increased risk of QT interval prolongation Details Domperidone Amlodipine Amvaz® Increased domperidone exposure and an increased risk of QT prolongation Details Domperidone Anagrelide Agrylin Increased risk of QT interval prolongation Details Domperidone Bedaquiline Sirturo Increased risk of QT interval prolongation Details Domperidone Chloroquine Aralen® Increased risk of QT interval prolongation Details Domperidone Cyclosporine Injection Atopica Increased domperidone exposure and an increased risk of QT prolongation Details Domperidone Cyclosporine Ophthalmic Cequa Increased domperidone exposure and an increased risk of QT prolongation Details Domperidone Dasatinib Phyrago An increased risk of QT interval prolongation Details Domperidone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Domperidone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Domperidone Disopyramide Norpace Increased risk of QT interval prolongation Details Domperidone Dofetilide Tikosyn Increased risk of QT interval prolongation Details Domperidone Dolasetron Anzemet Increased risk of QT interval prolongation Details Domperidone Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Domperidone Encorafenib Braftovi Increased risk of QT interval prolongation Details Domperidone Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Domperidone Eribulin Injection Halaven Increased risk of QT interval prolongation Details Domperidone Famotidine Calmicid Increased risk of QT interval prolongation Details Domperidone Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Domperidone Felbamate Felbatol Increased risk of QT interval prolongation Details Domperidone Flecainide Tambocor® Increased risk of QT interval prolongation Details Domperidone Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Domperidone Fostemsavir Rukobia Increased risk of torsade de pointes Details Domperidone Galantamine Razadyne Increased risk of QT interval prolongation Details Domperidone Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.