Anagrelide and Fluvoxamine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Anagrelide
Fluvoxamine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased anagrelide exposure and increased risk of bleeding
Interaction Deep Dive
Caution is advised with coadministration of anagrelide (a CYP1A2 substrate) and fluvoxamine (a CYP1A2 inhibitor) as this may increase anagrelide plasma concentrations. Coadministration of anagrelide and another drug that may increase the risk of bleeding, such as fluvoxamine, should also be undertaken with caution. If concurrent use is required, monitor patients for bleeding1.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated anagrelide metabolism; additive effects on hemostasis
Common questions
Can I take Anagrelide and Fluvoxamine together?
Increased anagrelide exposure and increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Anagrelide and Fluvoxamine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Anagrelide or Fluvoxamine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: AGRYLIN(R) oral capsules, anagrelide HCl oral capsules. Shire US Inc. (per FDA), Wayne, PA, 2014. DailyMed
Keep reading about Anagrelide
Keep reading about Fluvoxamine
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