Asenapine Transdermal Patch

377 interactions 1 explained in plain English 412 cited references

Also sold as: Secuado Secuado®

About Asenapine Transdermal Patch

Asenapine transdermal patches are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Asenapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain… Read the full Asenapine Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Metoclopramide Pimozide Piperaquine Bepridil

15 Contraindicated 276 Major 86 Moderate

All (377) Contraindicated (15) Major (276) Moderate (86)

Major

Asenapine Transdermal Patch Iloperidone Fanapt Increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Asenapine Transdermal Patch Imipramine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Inotuzumab Ozogamicin Besponsa Increased risk of QT-interval prolongation Details Asenapine Transdermal Patch Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Asenapine Transdermal Patch Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Asenapine Transdermal Patch Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Asenapine Transdermal Patch Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Itraconazole Sporanox An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Ivabradine Corlanor Increased risk of QT prolongation Details Asenapine Transdermal Patch Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Ketamine Increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Ketoconazole Extina Increased risk for QT interval prolongation Details Asenapine Transdermal Patch Kratom An increased risk of CNS depression Details Asenapine Transdermal Patch Lacosamide Motpoly An increased risk of CNS depression Details Asenapine Transdermal Patch Lapatinib Tykerb Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Lefamulin Xenleta Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Lemborexant Dayvigo An increased risk of CNS depression and potential next-day somnolence Details Asenapine Transdermal Patch Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Asenapine Transdermal Patch Leuprolide Eligard Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Levocetirizine Xyzal Increased risk of CNS depression Details Asenapine Transdermal Patch Levodopa Inbrija An increased risk of CNS depression Details Asenapine Transdermal Patch Levofloxacin Levaquin Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Levorphanol Xyvona An increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Asenapine Transdermal Patch Lofexidine Increased risk of CNS depressant effects and increased risk of QT interval prolongation Details Asenapine Transdermal Patch Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Asenapine Transdermal Patch Lopinavir An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Loxapine Adasuve Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Asenapine Transdermal Patch Lumefantrine An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Macimorelin Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Asenapine Transdermal Patch Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Mefloquine Lariam® Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Meperidine Demerol Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Asenapine Transdermal Patch Methadone Diskets Increased risk of respiratory and CNS depression and an increased risk of QT prolongation Details Asenapine Transdermal Patch Methocarbamol Atmeksi An increased risk of CNS depression Details Asenapine Transdermal Patch Methotrimeprazine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Metronidazole Flagyl An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Mifepristone Korlym Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.