Aspirin and Dichlorphenamide: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Aspirin
Dichlorphenamide
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased salicylate exposure , increased dichlorphenamide exposure and its toxicity
Interaction Deep Dive
Concomitant use of high-dose aspirin and dichlorphenamide is contraindicated as this may elevate salicylate levels and increase the risk of adverse effects, including anorexia, tachypnea, lethargy, and coma. Exercise caution with coadministration of low-dose aspirin and dichlorphenamide2. If administered, consider reducing the dose of the dichlorphenamide (a carbonic anhydrase inhibitor) and monitor patient for any adverse effects from dichlorphenamide. Concurrent use with aspirin can lead to high serum concentrations of dichlorphenamide and cause toxicity due to competition at the renal tubule for secretion 1.
Why it happens (mechanism)
Competition at the renal tubule for secretion
Common questions
Can I take Aspirin and Dichlorphenamide together?
Increased salicylate exposure , increased dichlorphenamide exposure and its toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aspirin and Dichlorphenamide interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Aspirin or Dichlorphenamide need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: CARISOPRODOL, ASPIRIN, CODEINE PHOSPHATE oral tablets, carisoprodol, aspirin, codeine phosphate oral tablets. Ingenus Pharmaceuticals LLC (per DailyMed), Orlando, FL, 2021. DailyMed
- Product Information: KEVEYIS(TM) oral tablets, dichlorphenamide oral tablets. TaroPharma (per manufacturer), Hawthorne, NY, 2015. DailyMed
Keep reading about Aspirin
Keep reading about Dichlorphenamide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist