Aspirin

465 interactions 7 explained in plain English 1,426 cited references
Also sold as: Acuprin® Anacin Aspirin Regimen Anacin® Aspirin Regimen Ascriptin® Aspergum Aspergum® Aspi-Cor Aspidrox® Aspir-Mox® Aspir-trin® Aspirtab® Bayer Aspirin Bayer® Aspirin Bufferin Bufferin® Buffex® Durlaza Easprin® Ecotrin Ecotrin® Empirin® Entaprin® Entercote® Fasprin® Genacote® Gennin-FC® Genprin® Halfprin® Magnaprin® Miniprin Miniprin® Minitabs® Norwich Aspirin Ridiprin® Sloprin® St. Joseph Aspirin Uni-Buff® Uni-Tren® Valomag® Vazalore Zorprin®
About Aspirin

Aspirin is a pain reliever and anti-inflammatory medication used to treat pain, fever, arthritis, and help prevent heart attacks and strokes. Read the full Aspirin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dichlorphenamide Influenza Virus Vaccine, Live Abrocitinib Defibrotide Injection Ketorolac Defibrotide
10 Contraindicated 327 Major 124 Moderate 4 Minor
All (465) Contraindicated (10) Major (327) Moderate (124) Minor (4)

Contraindicated

Aspirin Abrocitinib Cibinqo Explained Increased risk of bleeding Details Aspirin Defibrotide Increased risk of bleeding Details Aspirin Dichlorphenamide Increased salicylate exposure , increased dichlorphenamide exposure and its toxicity Details Aspirin Influenza Virus Vaccine, Live An increased risk of Reye's syndrome in children and adolescents 2 to 17 years of age Details Aspirin Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Aspirin Probenecid Salicylates antagonize the uricosuric effects of probenecid Details Aspirin Defibrotide Injection Defitelio Increased risk of bleeding Details Aspirin Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Aspirin Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Aspirin Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details

Major

Aspirin Amitriptyline Elavil Explained An increased risk of bleeding Details Aspirin Sertraline Explained An increased risk of bleeding Details Aspirin Lisinopril Prinivil Explained Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Aspirin Acetazolamide Diamox® Sequels® Salicylate toxicity (vomiting, tachycardia, hyperpnea, mental confusion) or acetaZOLAMIDE toxicity (fatigue, lethargy, somnolence,... Details Aspirin Amikacin Injection Amikin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Amikacin Oral Inhalation Arikayce Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Apixaban Eliquis Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Aspirin Aceclofenac An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Aspirin Acemetacin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Aspirin Acenocoumarol Increased risk of bleeding Details Aspirin Alclometasone An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Aldosterone An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Alipogene Tiparvovec An increased risk of bleeding Details Aspirin Alteplase, Recombinant Activase An increased risk of bleeding Details Aspirin Amcinonide An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Amikacin Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Aspirin Amineptine An increased risk of bleeding Details Aspirin Amitriptylinoxide An increased risk of bleeding Details Aspirin Amoxapine An increased risk of bleeding Details Aspirin Amphotericin B Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Amtolmetin Guacil An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Aspirin Anagrelide Agrylin An increased risk of bleeding Details Aspirin Anisindione An increased risk of bleeding Details Aspirin Ardeparin Increased risk of bleeding Details Aspirin Argatroban Increased risk of bleeding Details Aspirin Bacitracin Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Beclomethasone An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Aspirin Bemiparin Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.