Drug Interaction Report

Prasugrel and Aspirin: Interaction Details

A pharmacist-reviewed analysis of the Prasugrel and Aspirin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Prasugrel

Effient Effient®
+

Aspirin

Acuprin® Anacin Aspirin Regimen Anacin® Aspirin Regimen Ascriptin® Aspergum Aspergum® Aspi-Cor Aspidrox®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 11, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 49 documented Prasugrel interactions, 44 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of bleeding

Interaction Deep Dive

Concomitant use of aspirin and prasugrel, a platelet activation and aggregation inhibitor3, may increase the risk of bleeding events 1. Drug interaction studies showed aspirin did not alter prasugrel-mediated platelet aggregation inhibition but did result in increased bleeding time 3. If concurrent use is required, administer aspirin and prasugrel with care and monitor for signs and symptoms of bleeding 2.

Why it happens (mechanism)

Additive antiplatelet effects

Literature reports

1 report — tap to read

a) During drug interaction studies, coadministration of aspirin and prasugrel did not result in inhibition of prasugrel-mediated platelet aggregation, however, an increase in bleeding time was noted 3.

Common questions

Can I take Prasugrel and Aspirin together?

An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Prasugrel and Aspirin interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Prasugrel or Aspirin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: AGGRENOX(R) oral extended release capsules, aspirin dipyridamole oral extended release capsules. Boehringer Ingelheim Pharmaceuticals, Inc. (per FDA), Ridgefield, CT, 2012. DailyMed
  2. Product Information: CARISOPRODOL, ASPIRIN, CODEINE PHOSPHATE oral tablets, carisoprodol, aspirin, codeine phosphate oral tablets. Ingenus Pharmaceuticals LLC (per DailyMed), Orlando, FL, 2021. DailyMed
  3. Product Information: EFFIENT oral tablets, prasugrel oral tablets. Daiichi Sankyo, Inc. and Eli Lilly and Company (per FDA), Indianapolis, IN, 2011. DailyMed
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Prasugrel

Keep reading about Prasugrel

All Prasugrel interactions (49) Prasugrel drug information
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Aspirin

Keep reading about Aspirin

All Aspirin interactions (465) Aspirin drug information
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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Aspirin + Activated Charcoal Asarabacca Beer Danshen Piracetam Siberian Cocklebur Wine Aconite + 234 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.