Drug Interaction Report

Glyburide and Aspirin: Interaction Details

Name: Glyburide and Aspirin Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Glyburide and Aspirin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Aspirin

Acuprin® Anacin Aspirin Regimen Anacin® Aspirin Regimen Ascriptin® Aspergum Aspergum® Aspi-Cor Aspidrox®

Glyburide

DiaBeta® Glynase Glynase® Micronase®

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Jul 11, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 79 documented Glyburide interactions, 37 are rated moderate — including this one.

Onset

unspecified

Evidence

theoretical

Severity

Moderate

What happens

Increased risk of hypoglycemia

Interaction Deep Dive

The effectiveness of oral hypoglycemic drugs may be increased with concomitant use of moderate doses of aspirin. This may lead to hypoglycemia. Monitor blood sugar carefully if concomitant use is required¹.

Why it happens (mechanism)

Increased effectiveness of oral hypoglycemic agent

Common questions

Can I take Glyburide and Aspirin together?

Increased risk of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.

How serious is the Glyburide and Aspirin interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

Does my dose of Glyburide or Aspirin need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (1)

Product Information: YOSPRALA(TM) oral delayed-release tablets, aspirin, omeprazole oral delayed-release tablets. Aralez Pharmaceuticals US Inc (per manufacturer), Princeton, NJ, 2016. DailyMed

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Aspirin

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All Aspirin interactions (465) Aspirin drug information

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Glyburide

Keep reading about Glyburide

All Glyburide interactions (79) Glyburide drug information

Also serious with: Moxifloxacin Ophthalmic Disopyramide Belumosudil Orlistat

Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Aspirin + Activated Charcoal Asarabacca Beer Danshen Piracetam Siberian Cocklebur Wine Aconite + 234 more

Glyburide + Activated Charcoal Apple Beer Grapefruit Siberian Cocklebur Sweet Orange Wine Acai + 323 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.