Atorvastatin and Bezafibrate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 15, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Atorvastatin
Bezafibrate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased incidence and severity of myopathy
Interaction Deep Dive
Concomitant use of bezafibrate and an HMG-CoA reductase inhibitor increases the incidence and severity of myopathy. The concomitant use is contraindicated in patients with predisposing factors for myopathy (eg, renal impairment, age greater than 65 years, personal or family history of hereditary muscular disorders and previous history of muscular toxicity with a fibrate or other lipid lowering drug, hypothyroidism, severe infection, trauma, surgery, disturbances of hormone or electrolyte imbalance, and a high alcohol intake). If coadministration is necessary, a dosage reduction of the HMG-CoA reductase inhibitor may be needed. Monitor for signs and symptoms of myopathy and increased creatine kinase levels. Discontinue concomitant use if signs of myopathy occur1.
Why it happens (mechanism)
Additive myopathy effect
Common questions
Can I take Atorvastatin and Bezafibrate together?
Increased incidence and severity of myopathy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Atorvastatin and Bezafibrate interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Atorvastatin or Bezafibrate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Bezalip Mono oral modified-release tablets, bezafibrate oral modified-release tablets. Actavis Group PTC ehf (per eMC+), Hafnarfjordur, Iceland, 2015. DailyMed
Keep reading about Atorvastatin
Keep reading about Bezafibrate
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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