Atropine Ophthalmic

64 interactions 238 cited references
Also sold as: Atropine Care 1% Atropisol® Isopto® Atropine Ocu-Tropine®
About Atropine Ophthalmic

Ophthalmic atropine is used before eye examinations to dilate (open) the pupil, the black part of the eye through which you see. It is also used to relieve pain caused by swelling and inflammation of the eye. Read the full Atropine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ambenonium Potassium Citrate Potassium Chloride Alfentanil Amantadine Amifampridine
3 Contraindicated 54 Major 4 Moderate 3 Minor
All (64) Contraindicated (3) Major (54) Moderate (4) Minor (3)

Major

Atropine Ophthalmic Alfentanil An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Atropine Ophthalmic Amantadine Potentiation of anticholinergic effects Details Atropine Ophthalmic Amifampridine Increased risk of seizures Details Atropine Ophthalmic Benzhydrocodone Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Buprenorphine Belbuca An increased risk of paralytic ileus Details Atropine Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Atropine Ophthalmic Clomipramine Anafranil An increased risk of anticholinergic effects and an increased risk of seizures Details Atropine Ophthalmic Clozapine Clozaril Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Atropine Ophthalmic Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) An increased risk of paralytic ileus Details Atropine Ophthalmic Cyclobenzaprine Amrix An increased risk of atropine-like adverse reactions Details Atropine Ophthalmic Dihydrocodeine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Donepezil Adlarity Reduced seizure threshold Details Atropine Ophthalmic Epinephrine An increased risk of cardiac arrhythmias Details Atropine Ophthalmic Fentanyl Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Atropine Ophthalmic Glucagon Increased risk of gastrointestinal side effects Details Atropine Ophthalmic Glycopyrrolate Cuvposa An increased risk of anticholinergic side effects Details Atropine Ophthalmic Glycopyrronium Tosylate An increased risk of anticholinergic side effects Details Atropine Ophthalmic Hydrocodone Hysingla Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Hydromorphone Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures Details Atropine Ophthalmic Isocarboxazid Marplan Potential to cause hypertensive crisis Details Atropine Ophthalmic Letibotulinumtoxina-Wlbg Letybo Increased neuromuscular weakness and heightened systemic anticholinergic effects Details Atropine Ophthalmic Linezolid Zyvox Potential to cause hypertensive crisis Details Atropine Ophthalmic Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Atropine Ophthalmic Meperidine Demerol Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Mesoridazine An increased risk of CNS depression Details Atropine Ophthalmic Methacholine Inhibition of the airway response to methacholine Details Atropine Ophthalmic Methadone Diskets Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Methylene Blue Provayblue Potential to cause hypertensive crisis Details Atropine Ophthalmic Moclobemide Potential to cause hypertensive crisis Details Atropine Ophthalmic Morphine Increased risk of urinary retention, severe constipation, and paralytic ileus Details Atropine Ophthalmic Morphine Sulfate Liposome Increased risk of urinary retention, severe constipation, and paralytic ileus Details Atropine Ophthalmic Nialamide Potential to cause hypertensive crisis Details Atropine Ophthalmic Olanzapine Increased risk of severe gastrointestinal adverse reactions Details Atropine Ophthalmic Oliceridine Olinvyk Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Oxycodone Oxaydo An increased risk of paralytic ileus Details Atropine Ophthalmic Oxymorphone Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Atropine Ophthalmic Phenelzine Nardil Potential to cause hypertensive crisis Details Atropine Ophthalmic Procarbazine Potential to cause hypertensive crisis Details Atropine Ophthalmic Promethazine Phenadoz Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.