Bexarotene and Estradiol Topical: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Estradiol Topical
Bexarotene
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased contraceptive effectiveness
Interaction Deep Dive
Bexarotene can potentially increase the rate of metabolism and reduce plasma concentrations of other substrates metabolized by CYP3A4, including hormonal contraceptives. If concomitant use cannot be avoided, two reliable forms of contraception are strongly recommended, one of which should be non-hormonal1.
Why it happens (mechanism)
Induction of metabolic enzymes by bexarotene
Common questions
Can I take Bexarotene and Estradiol Topical together?
Decreased contraceptive effectiveness Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bexarotene and Estradiol Topical interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Bexarotene or Estradiol Topical need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Targretin(R), bexarotene. Ligan Pharmaceuticals Incorporated, San Diego, CA, 2000. DailyMed
Keep reading about Estradiol Topical
Keep reading about Bexarotene
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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