Drug Interaction Report

Bromocriptine and Octreotide: Interaction Details

A pharmacist-reviewed analysis of the Bromocriptine and Octreotide interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Octreotide

Bynfezia Mycapssa Mycapssa® Sandostatin
+

Bromocriptine

Cycloset Cycloset® Parlodel Parlodel®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 16 documented Bromocriptine interactions, 3 are rated moderate — including this one.
Onset
delayed
Evidence
theoretical
Severity
Moderate

What happens

Increased bromocriptine exposure

Interaction Deep Dive

Concomitant administration of octreotide and bromocriptine may increase the systemic exposure of bromocriptine213. Dose adjustment of bromocriptine may be necessary 2.

Why it happens (mechanism)

Unknown

Common questions

Can I take Bromocriptine and Octreotide together?

Increased bromocriptine exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Bromocriptine and Octreotide interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Bromocriptine or Octreotide need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Product Information: BYNFEZIA PEN(TM) subcutaneous injection, octreotide acetate subcutaneous injection. Sun Pharmaceutical Industries Inc (per FDA), Cranbury, NJ, 2020. DailyMed
  2. Product Information: MYCAPSSA(R) oral delayed-release capsules, octreotide oral delayed-release capsules. Chiasma Inc (per manufacturer), Cincinnati, OH, 2020. DailyMed
  3. Product Information: SANDOSTATIN(R) LAR DEPOT intramuscular injection suspension, octreotide acetate intramuscular injection suspension. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2019.
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Octreotide

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All Octreotide interactions (380) Octreotide drug information
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Bromocriptine

Keep reading about Bromocriptine

All Bromocriptine interactions (16) Bromocriptine drug information
Also serious with: Letermovir Injection Ketoconazole Topical Dihydroergotamine Injection Dihydroergotamine Nasal Spray
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Octreotide + Activated Charcoal Adrafinil Cannabidiol (cbd) Cannabinol (cbn) Cannabis Coffee Charcoal Delta-9-tetrahydrocannabinol (thc) Ergot + 22 more
Bromocriptine + Activated Charcoal Grapefruit St. John's Wort Acacia Rigidula Adrafinil African Wild Potato American Elder Astaxanthin + 135 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.