Butabarbital

30 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Butabarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Butabarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Butabarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Butabarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Butabarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Butabarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Butabarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Butabarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Butabarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Butabarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Butabarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Butabarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Butabarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Butabarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Butabarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Butabarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Butabarbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Butabarbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Butabarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Butabarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Butabarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Butabarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Butabarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Butabarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.