Butorphanol Nasal Spray

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Major

Butorphanol Nasal Spray Lofexidine Increased risk of CNS depressant effects Details Butorphanol Nasal Spray Lorazepam Ativan Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Lorcaserin Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Loxapine Adasuve Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Butorphanol Nasal Spray Meclizine Antivert Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Melitracen Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Melperone Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Meperidine Demerol Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Mephobarbital Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Meprobamate Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Meptazinol Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Mesoridazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Metaxalone Skelaxin Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Butorphanol Nasal Spray Methadone Diskets Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Methamphetamine Desoxyn An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Methdilazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Methocarbamol Atmeksi Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Methohexital Brevital Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Methotrimeprazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Methylene Blue Provayblue Increased risk of serotonin syndrome or opioid toxicity Details Butorphanol Nasal Spray Metoclopramide Increased risk of CNS depression Details Butorphanol Nasal Spray Midazolam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Milnacipran Savella Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Mirtazapine Mirataz Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Molindone Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Moricizine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Morphine Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Morphine Sulfate Liposome Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Nalbuphine Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Naratriptan Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Nefazodone Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Nicomorphine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Nitrazepam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Nitrous Oxide Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Nortriptyline Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Olanzapine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Oliceridine Olinvyk Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression and reduced anal... Details Butorphanol Nasal Spray Ondansetron Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Opipramol Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.