Butorphanol Nasal Spray

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Contraindicated

Butorphanol Nasal Spray Isocarboxazid Marplan An increased risk of CNS depression Details Butorphanol Nasal Spray Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Butorphanol Nasal Spray Phenelzine Nardil An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Safinamide Xadago Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Butorphanol Nasal Spray Tranylcypromine Parnate An increased risk of serotonin syndrome and an increased risk of CNS depression Details

Major

Butorphanol Nasal Spray Acepromazine PROMACE Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Alfentanil An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Butorphanol Nasal Spray Almotriptan Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Alprazolam Xanax Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Amifampridine Increased risk of seizures Details Butorphanol Nasal Spray Amineptine Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Amitriptyline Elavil Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Amitriptylinoxide Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Amobarbital Amytal Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Amoxapine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Amphetamine Dexedrine An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Aripiprazole Abilify Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Asenapine Saphris Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Baclofen Fleqsuvy Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Benperidol Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Benzhydrocodone Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Benzphetamine An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Bromazepam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Bromopride Potentiation of sedative effects Details Butorphanol Nasal Spray Brompheniramine Respa-BR Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Buprenorphine Belbuca Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Bupropion Aplenzin Increased risk of seizures Details Butorphanol Nasal Spray Buspirone Bucapsol Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Butabarbital Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Butalbital An increased risk of CNS depression Details Butorphanol Nasal Spray Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Butorphanol Nasal Spray Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Butorphanol Nasal Spray Cannabis An increased risk of CNS depression Details Butorphanol Nasal Spray Carbamazepine Carbatrol Increased risk of serotonin syndrome and an increased risk of respiratory depression, profound sedation, hypotension and syncope Details Butorphanol Nasal Spray Carbidopa Lodosyn An increased risk of CNS depression Details Butorphanol Nasal Spray Carbinoxamine Carbzah An increased risk of CNS depression Details Butorphanol Nasal Spray Carisoprodol Soma Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Carphenazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Cetirizine Aller-Tec Increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.