Butorphanol Nasal Spray

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Major

Butorphanol Nasal Spray Chloral Hydrate Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Chlordiazepoxide Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Chlorpheniramine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Chlorpromazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Chlorzoxazone Lorzone Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Citalopram Celexa Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Clobazam Onfi Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Clomipramine Anafranil Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Clonazepam Klonopin Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Clopidogrel Plavix Reduced efficacy of clopidogrel Details Butorphanol Nasal Spray Clorazepate Tranxene Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Clozapine Clozaril Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Cocaine Goprelto Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Butorphanol Nasal Spray Cyclobenzaprine Amrix Increased risk of serotonin syndrome and an increased risk of CNS depression Details Butorphanol Nasal Spray Cyproheptadine An increased risk of CNS depression Details Butorphanol Nasal Spray Daridorexant An increased risk CNS depression Details Butorphanol Nasal Spray Desipramine Norpramin Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Desvenlafaxine Pristiq Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Dexmedetomidine Dexased Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Dextroamphetamine Dexedrine An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Dextromethorphan Delsym Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Dezocine Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Diazepam Diastat Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Dibenzepin Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Dichloralphenazone Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Difenoxin Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Dihydrocodeine Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Diphenhydramine Banophen Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Diphenoxylate Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Dolasetron Anzemet Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Donepezil Adlarity Reduced seizure threshold Details Butorphanol Nasal Spray Doxepin Prudoxin Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Droperidol Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Duloxetine Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Eletriptan Relpax Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Enflurane Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Escitalopram Lexapro Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Esketamine Spravato Increased risk of sedation Details Butorphanol Nasal Spray Estazolam Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.