Butorphanol Nasal Spray

Name: Butorphanol Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Moderate

Butorphanol Nasal Spray Brimonidine Alphagan An increased risk of CNS depression Details Butorphanol Nasal Spray Carbachol Isopto Carbachol An increased risk of CNS depression Details Butorphanol Nasal Spray Clonidine Duraclon An increased risk of sedation and somnolence Details Butorphanol Nasal Spray Desflurane Suprane Reduced desflurane (MAC) exposure needed to produce anesthesia Details Butorphanol Nasal Spray Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Butorphanol Nasal Spray Ganaxolone Ztalmy An increased risk of somnolence and sedation Details Butorphanol Nasal Spray Sevoflurane Petrem Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.