Butorphanol Nasal Spray

Name: Butorphanol Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Contraindicated

Butorphanol Nasal Spray Isocarboxazid Marplan An increased risk of CNS depression Details Butorphanol Nasal Spray Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Butorphanol Nasal Spray Phenelzine Nardil An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Safinamide Xadago Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Butorphanol Nasal Spray Tranylcypromine Parnate An increased risk of serotonin syndrome and an increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.