Butorphanol Nasal Spray

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Major

Butorphanol Nasal Spray Eszopiclone Lunesta Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ethchlorvynol Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ethopropazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ethylmorphine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Fenfluramine An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Butorphanol Nasal Spray Fentanyl Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Flibanserin Addyi Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Fluoxetine RECONCILE Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Fluphenazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Flurazepam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Fluspirilene Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Fluvoxamine Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Foscarbidopa An increased risk of CNS depression Details Butorphanol Nasal Spray Foslevodopa An increased risk of CNS depression Details Butorphanol Nasal Spray Fospropofol Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Frovatriptan Frova Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Gabapentin Gabarone An increased risk of serious and/or fatal respiratory depression and sedation Details Butorphanol Nasal Spray Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Butorphanol Nasal Spray Gepirone Exxua An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Granisetron Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Halazepam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Haloperidol Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Halothane Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Hexobarbital Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Hydrocodone Hysingla Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Hydromorphone Dilaudid Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Hydroxyamphetamine An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Hydroxychloroquine Plaquenil An increased risk of seizures Details Butorphanol Nasal Spray Hydroxytryptophan Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Hydroxyzine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Isoflurane Fluriso Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ketamine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ketazolam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ketobemidone Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Kratom Increased risk of CNS depression and serotonin syndrome Details Butorphanol Nasal Spray Lacosamide Motpoly An increased risk of CNS depression Details Butorphanol Nasal Spray Lasmiditan Reyvow Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Butorphanol Nasal Spray Lemborexant Dayvigo An increased risk of CNS depression and potential next-day somnolence Details Butorphanol Nasal Spray Levocetirizine Xyzal Increased risk of CNS depression Details Butorphanol Nasal Spray Levodopa Inbrija An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.