Butorphanol Nasal Spray

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Major

Butorphanol Nasal Spray Opium Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Opium Alkaloids Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Orphenadrine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Oxazepam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Oxycodone Oxaydo Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Oxymorphone Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Ozanimod Increased risk of serious adverse reactions Details Butorphanol Nasal Spray Paliperidone Erzofri An increased risk of CNS depression Details Butorphanol Nasal Spray Palonosetron Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Papaveretum Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Paregoric Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Paroxetine Paxil Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Pentazocine Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Pentobarbital Fatal-Plus Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Perampanel FYCOMPA Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Perazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Periciazine Risk of enhanced CNS depression Details Butorphanol Nasal Spray Perphenazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Phenobarbital Fidoquel Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Pimozide Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Piperacetazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Pipotiazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Piritramide Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Potassium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Butorphanol Nasal Spray Prazepam Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Pregabalin Bonqat An increased risk of respiratory depression Details Butorphanol Nasal Spray Primidone Mysoline Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Procarbazine Increased risk of serotonin syndrome or opioid toxicity Details Butorphanol Nasal Spray Prochlorperazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Promazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Promethazine Phenadoz Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Propofol Diprivan Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Protriptyline Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Quazepam Doral Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Quetiapine Seroquel Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Ramelteon Rozerem Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Rasagiline Azilect Increased risk of serotonin syndrome or opioid toxicity Details Butorphanol Nasal Spray Remifentanil Increased risk of CNS and respiratory depression, profound sedation, hypotension, coma and death, reduced analgesic effect or prec... Details Butorphanol Nasal Spray Remimazolam Byfavo Increased risk of profound sedation, respiratory depression, coma, and death Details Butorphanol Nasal Spray Remoxipride Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.