Butorphanol Nasal Spray

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Major

Butorphanol Nasal Spray Rizatriptan Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Ropeginterferon Alfa-2B-Njft Besremi Increased risk of sedation Details Butorphanol Nasal Spray Scopolamine Pamine Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Butorphanol Nasal Spray Secobarbital Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Selegiline Anipryl Increased risk of serotonin syndrome or opioid toxicity Details Butorphanol Nasal Spray Sertindole Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Sertraline Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Sibutramine Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Sodium Oxybate Lumryz An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Butorphanol Nasal Spray St John's Wort Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Sufentanil Dsuvia Reduced analgesic effect of SUFentanil and an increased risk of serotonin syndrome Details Butorphanol Nasal Spray Sulpiride Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Sumatriptan Imitrex Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Suvorexant Belsomra Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Tapentadol Nucynta Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome, respiratory depress... Details Butorphanol Nasal Spray Tedizolid Phosphate Sivextro An increased risk of serotonin syndrome Details Butorphanol Nasal Spray Temazepam Restoril Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Thiethylperazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Thiopental Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Thiopropazate Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Thioridazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Tianeptine Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Ticagrelor Brilinta Reduced absorption of ticagrelor Details Butorphanol Nasal Spray Tilidine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Tizanidine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Tolonium Chloride Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Topiramate Eprontia Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Tramadol ConZip Reduced efficacy of traMADol, an increased risk of withdrawal symptoms, an increased risk of serotonin syndrome and an increased r... Details Butorphanol Nasal Spray Trazodone Raldesy An increased risk of serotonin syndrome and an increased risk of CNS depression Details Butorphanol Nasal Spray Triazolam Halcion Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Trifluoperazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Trifluperidol Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Triflupromazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Trimeprazine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Trimipramine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Tryptophan Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Venlafaxine Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Vilazodone Viibryd Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Vortioxetine Trintellix Increased risk of serotonin syndrome Details Butorphanol Nasal Spray Zaleplon Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.