Butorphanol Nasal Spray

Name: Butorphanol Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

258 interactions 299 cited references

Also sold as: Stadol® NS

About Butorphanol Nasal Spray

Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain. Read the full Butorphanol Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid

6 Contraindicated 245 Major 7 Moderate

All (258) Contraindicated (6) Major (245) Moderate (7)

Major

Butorphanol Nasal Spray Ziprasidone Geodon Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) and an increased risk of CNS... Details Butorphanol Nasal Spray Zolpidem Ambien Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Zopiclone Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Zotepine Increased risk of respiratory and CNS depression Details Butorphanol Nasal Spray Zuranolone Zurzuvae An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.