Cariprazine

Name: Cariprazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

157 interactions 138 explained in plain English 311 cited references

Also sold as: Vraylar Vraylar®

About Cariprazine

Cariprazine is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and depression. Read the full Cariprazine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 16, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bromopride Ensitrelvir Metoclopramide Injection Metoclopramide Nasal Spray Metoclopramide Nafcillin Injection

5 Contraindicated 148 Major 4 Moderate

All (157) Contraindicated (5) Major (148) Moderate (4)

Moderate

Cariprazine Artemether Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Cariprazine Kratom Explained Increased CYP3A substrate exposure Details Cariprazine Mavacamten Camzyos Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Cariprazine Rilzabrutinib Wayrilz Explained Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.