Caspofungin

Name: Caspofungin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Cyclosporine Injection Cyclosporine Ophthalmic Mercaptopurine Methotrexate Methotrexate Injection

6 Major 3 Moderate

All (9) Major (6) Moderate (3)

Major

Caspofungin Azathioprine Azasan An increased risk of hepatotoxicity Details Caspofungin Cyclosporine Injection Atopica Increased plasma levels of caspofungin and increased risk of hepatic enzyme elevations Details Caspofungin Cyclosporine Ophthalmic Cequa Increased plasma levels of caspofungin and increased risk of hepatic enzyme elevations Details Caspofungin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Caspofungin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Caspofungin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Caspofungin Dexamethasone Injection Decadron Reduced caspofungin plasma levels Details Caspofungin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced caspofungin plasma levels Details Caspofungin Nevirapine Viramune Reduced caspofungin plasma levels Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.