Cefaclor

31 interactions 211 cited references
Also sold as: Ceclor® Ceclor® CD Raniclor®
About Cefaclor

Cefaclor is used to treat certain infections caused by bacteria, such as pneumonia and other lower respiratory tract (lung) infections; and infections of the skin, ears, throat, tonsils, and urinary tract. Cefaclor is in a class of medications called cephalosporin antibiotics. It works by stopping the growth of bacteri… Read the full Cefaclor drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cefaclor Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Cefaclor Desogestrel Decreased contraceptive effectiveness Details Cefaclor Dienogest Decreased contraceptive effectiveness Details Cefaclor Drospirenone Decreased contraceptive effectiveness Details Cefaclor Estradiol Delestrogen Decreased contraceptive effectiveness Details Cefaclor Ethinyl Estradiol Decreased contraceptive effectiveness Details Cefaclor Ethynodiol Decreased contraceptive effectiveness Details Cefaclor Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefaclor Furosemide Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefaclor Gestodene Decreased contraceptive effectiveness Details Cefaclor Leflunomide Arava Increased exposure of OAT3 substrate Details Cefaclor Levonorgestrel After banger Decreased contraceptive effectiveness Details Cefaclor Mestranol Decreased contraceptive effectiveness Details Cefaclor Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cefaclor Nitisinone Increased OAT1 or OAT3 substrate exposure and an increased risk of OAT1 or OAT3 substrate-related adverse effects Details Cefaclor Nomegestrol Decreased contraceptive effectiveness Details Cefaclor Norethindrone Aygestin Decreased contraceptive effectiveness Details Cefaclor Norgestimate Decreased contraceptive effectiveness Details Cefaclor Norgestrel Decreased contraceptive effectiveness Details Cefaclor Teriflunomide Aubagio Increased exposure of OAT3 substrate Details Cefaclor Vadadustat Vafseo Increased cefaclor exposure and an increased risk of cefaclor-related adverse effect Details Cefaclor Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cefaclor Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cefaclor Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefaclor Furosemide Injection Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefaclor Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Cefaclor Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.