Cefprozil

27 interactions 100 cited references
Also sold as: Cefzil®
About Cefprozil

Cefprozil is a cephalosporin antibiotic used to treat bacterial infections of the airways, skin, ears, sinuses, throat, and tonsils. Read the full Cefprozil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cholera Vaccine, Live Desogestrel Dienogest Drospirenone Estradiol Ethinyl Estradiol
23 Major 4 Moderate
All (27) Major (23) Moderate (4)

Major

Cefprozil Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Cefprozil Desogestrel Decreased contraceptive effectiveness Details Cefprozil Dienogest Decreased contraceptive effectiveness Details Cefprozil Drospirenone Decreased contraceptive effectiveness Details Cefprozil Estradiol Delestrogen Decreased contraceptive effectiveness Details Cefprozil Ethinyl Estradiol Decreased contraceptive effectiveness Details Cefprozil Ethynodiol Decreased contraceptive effectiveness Details Cefprozil Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefprozil Furosemide Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefprozil Gestodene Decreased contraceptive effectiveness Details Cefprozil Levonorgestrel After banger Decreased contraceptive effectiveness Details Cefprozil Mestranol Decreased contraceptive effectiveness Details Cefprozil Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cefprozil Nomegestrol Decreased contraceptive effectiveness Details Cefprozil Norethindrone Aygestin Decreased contraceptive effectiveness Details Cefprozil Norgestimate Decreased contraceptive effectiveness Details Cefprozil Norgestrel Decreased contraceptive effectiveness Details Cefprozil Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cefprozil Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cefprozil Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefprozil Furosemide Injection Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefprozil Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Cefprozil Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Cefprozil Lixisenatide Delayed therapeutic effect Details Cefprozil Probenecid Increased serum cefprozil levels Details Cefprozil Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Cefprozil Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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