Chloroquine and Pixantrone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Pixantrone
No brand names on recordChloroquine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of CYP2C8 substrates
Interaction Deep Dive
Concomitant use of pixantrone (a CYP2C8 inhibitor) with a CYP2C8 substrate may increase exposure of the CYP2C8 substrate. If concomitant use is required, careful monitoring for side effects associated with increased concentrations of the CYP2C8 substrate is recommended1.
Why it happens (mechanism)
Inhibition of CYP2C8-mediated metabolism by pixantrone
Common questions
Can I take Chloroquine and Pixantrone together?
Increased exposure of CYP2C8 substrates Always confirm with your pharmacist or prescriber before making any change.
How serious is the Chloroquine and Pixantrone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Chloroquine or Pixantrone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Pixuvri intravenous injection powder concentrate, pixantrone intravenous injection powder concentrate. CTI Life Sciences Limited (per EMA), Hertforshire, United Kingdom, 2012.
Keep reading about Pixantrone
Keep reading about Chloroquine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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