Chloroquine

332 interactions 586 cited references

Also sold as: Aralen®

About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole

14 Contraindicated 294 Major 23 Moderate 1 Minor

All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Major

Chloroquine Chlorpropamide Diabinese® Hypoglycemia Details Chloroquine Cimetidine Tagamet Chloroquine toxicity Details Chloroquine Ciprofloxacin Increased ciprofloxacin urinary excretion and an increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Citalopram Celexa An increased risk of QT interval prolongation Details Chloroquine Clarithromycin Biaxin Increased risk of QT interval prolongation Details Chloroquine Clofazimine An increased risk of QT interval prolongation Details Chloroquine Clomipramine Anafranil An increased risk of QT interval prolongation and an increased risk of seizures Details Chloroquine Clothiapine Increased risk of cardiac arrhythmias Details Chloroquine Clozapine Clozaril Increased risk of QT interval prolongation Details Chloroquine Crizotinib Xalkori An increased risk of QT interval prolongation Details Chloroquine Cyclobenzaprine Amrix Increased risk of QT-interval prolongation Details Chloroquine Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Chloroquine Dapagliflozin Farxiga Hypoglycemia Details Chloroquine Dasatinib Phyrago An increased risk of QT interval prolongation Details Chloroquine Degarelix Firmagon Increased risk of QT interval prolongation Details Chloroquine Delamanid Increased risk of QT interval prolongation Details Chloroquine Desflurane Suprane An increased risk of QT interval prolongation Details Chloroquine Desipramine Norpramin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Chloroquine Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Chloroquine Dibenzepin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Dofetilide Tikosyn Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Domperidone Increased risk of QT interval prolongation Details Chloroquine Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Chloroquine Dordaviprone An increased risk of QT interval prolongation Details Chloroquine Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Droperidol An increased risk of QT interval prolongation Details Chloroquine Dulaglutide Trulicity Hypoglycemia Details Chloroquine Ebastine Increased risk of QT-interval prolongation Details Chloroquine Efavirenz An increased risk of QT interval prolongation Details Chloroquine Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia Details Chloroquine Encorafenib Braftovi Increased risk of QT interval prolongation Details Chloroquine Enflurane An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Chloroquine Eribulin Halaven Increased risk of QT-interval prolongation Details Chloroquine Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Chloroquine Escitalopram Lexapro An increased risk of QT interval prolongation Details Chloroquine Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.