Chloroquine

332 interactions 586 cited references

Also sold as: Aralen®

About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole

14 Contraindicated 294 Major 23 Moderate 1 Minor

All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Major

Chloroquine Amitriptyline Elavil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Sertraline An increased risk of QT interval prolongation Details Chloroquine Buprenorphine Belbuca An increased risk of QT interval prolongation Details Chloroquine Relugolix Orgovyx Increased risk of QT interval prolongation Details Chloroquine Acarbose Prandase® Hypoglycemia Details Chloroquine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Chloroquine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Chloroquine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Chloroquine Azithromycin AzaSite An increased risk of QT interval prolongation Details Chloroquine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Chloroquine Alogliptin Nesina Hypoglycemia Details Chloroquine Anagrelide Agrylin Increased risk of QT interval prolongation Details Chloroquine Bedaquiline Sirturo Increased risk of QT-interval prolongation Details Chloroquine Canagliflozin Invokana Hypoglycemia Details Chloroquine Acecainide Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Chloroquine Agalsidase Alfa Decreased efficacy of agalsidase alfa Details Chloroquine Ajmaline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Albiglutide Hypoglycemia Details Chloroquine Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Chloroquine Amoxapine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Apomorphine Apokyn An increased risk of QT interval prolongation Details Chloroquine Aprindine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Aripiprazole Abilify An increased risk of QT interval prolongation Details Chloroquine Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Chloroquine Artemether An increased risk of QT interval prolongation Details Chloroquine Articaine An increased risk of methemoglobinemia Details Chloroquine Asenapine Saphris Increased risk of QT interval prolongation Details Chloroquine Astemizole An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Atazanavir Reyataz Increased risk of QT-interval prolongation Details Chloroquine Azimilide Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Bretylium Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Bupropion Aplenzin Increased risk of seizures Details Chloroquine Carbamazepine Carbatrol Reduced carBAMazepine activity Details Chloroquine Ceritinib Zykadia An increased risk of QT interval prolongation Details Chloroquine Chloral Hydrate An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Chlorpromazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.