Chloroquine

332 interactions 586 cited references
Also sold as: Aralen®
About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole
14 Contraindicated 294 Major 23 Moderate 1 Minor
All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Moderate

Chloroquine Ampicillin Amcill® Decreased chloroquine bioavailability Details Chloroquine Ampicillin Injection Omnipen-N® Decreased chloroquine bioavailability Details Chloroquine Aluminum Carbonate, Basic Decreased efficacy of chloroquine Details Chloroquine Aluminum Hydroxide AlternaGEL® Decreased efficacy of chloroquine Details Chloroquine Aluminum Phosphate Decreased efficacy of chloroquine Details Chloroquine Calcium Carbonate Alka-Mints Decreased efficacy of chloroquine Details Chloroquine Cholera Vaccine, Live Reduced immune response to cholera vaccine Details Chloroquine Cyclosporine Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Chloroquine Digoxin Cardoxin® Increased serum digoxin concentration Details Chloroquine Dihydroxyaluminum Aminoacetate Decreased efficacy of chloroquine Details Chloroquine Dihydroxyaluminum Sodium Carbonate Decreased efficacy of chloroquine Details Chloroquine Kaolin Pet Pectillin Decreased efficacy of chloroquine Details Chloroquine Lanthanum Carbonate Fosrenol Reduced bioavailability of antimalarials Details Chloroquine Magaldrate Decreased efficacy of chloroquine Details Chloroquine Magnesium Carbonate Decreased efficacy of chloroquine Details Chloroquine Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased efficacy of chloroquine Details Chloroquine Magnesium Oxide Mag-Ox 400 Decreased efficacy of chloroquine Details Chloroquine Magnesium Trisilicate Decreased efficacy of chloroquine Details Chloroquine Praziquantel Biltricide Decreased praziquantel bioavailability Details Chloroquine Sodium Bicarbonate Alka-Seltzer® Heartburn Decreased efficacy of chloroquine Details Chloroquine Cyclosporine Injection Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Chloroquine Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Chloroquine Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.