Chloroquine

332 interactions 586 cited references

Also sold as: Aralen®

About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole

14 Contraindicated 294 Major 23 Moderate 1 Minor

All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Major

Chloroquine Insulin Detemir Levemir Hypoglycemia Details Chloroquine Insulin Glulisine Apidra Hypoglycemia Details Chloroquine Insulin Lispro, Recombinant Admelog Hypoglycemia Details Chloroquine Isoflurane Fluriso An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Itraconazole Sporanox Increased risk of QT-interval prolongation Details Chloroquine Ivabradine Corlanor Increased risk of QT prolongation Details Chloroquine Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Chloroquine Ketoconazole Extina Increased risk of QT interval prolongation Details Chloroquine Lapatinib Tykerb An increased risk of QT interval prolongation Details Chloroquine Lefamulin Xenleta Increased risk of QT interval prolongation Details Chloroquine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Chloroquine Leuprolide Eligard Increased risk of QT interval prolongation Details Chloroquine Levofloxacin Levaquin Increased risk of QT interval prolongation Details Chloroquine Lidocaine Akten An increased risk of methemoglobinemia Details Chloroquine Lidoflazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Linagliptin Tradjenta Hypoglycemia Details Chloroquine Liraglutide Saxenda Hypoglycemia Details Chloroquine Lixisenatide Hypoglycemia Details Chloroquine Lofexidine Increased risk of QT interval prolongation Details Chloroquine Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Chloroquine Lopinavir An increased risk of QT interval prolongation Details Chloroquine Lumefantrine An increased risk of QT interval prolongation Details Chloroquine Macimorelin Increased risk of QT interval prolongation Details Chloroquine Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Mefloquine Lariam® An increased risk of convulsions, electrocardiogram abnormalities, cardiac arrest Details Chloroquine Metformin Fortamet® Hypoglycemia Details Chloroquine Methadone Diskets Increased risk of QT interval prolongation Details Chloroquine Methotrimeprazine Increased risk of QT-interval prolongation Details Chloroquine Metronidazole Flagyl An increased risk of QT interval prolongation Details Chloroquine Mifepristone Korlym An increased risk of QT interval prolongation Details Chloroquine Miglitol Glyset® Hypoglycemia Details Chloroquine Milsaperidone An increased risk of QT interval prolongation Details Chloroquine Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Chloroquine Mizolastine Increased risk of QT-interval prolongation Details Chloroquine Mobocertinib Exkivity An increased risk of QT interval prolongation Details Chloroquine Moricizine Increased risk of QT-interval prolongation Details Chloroquine Moxifloxacin Avelox Increased risk of QT interval prolongation Details Chloroquine Nateglinide Starlix® Hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.