Chloroquine

332 interactions 586 cited references

Also sold as: Aralen®

About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole

14 Contraindicated 294 Major 23 Moderate 1 Minor

All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Major

Chloroquine Quinine An increased risk of QT interval prolongation Details Chloroquine Quizartinib Vanflyta An increased risk of QT interval prolongation Details Chloroquine Rabies Vaccine Imovax Decreased antibody response Details Chloroquine Ranolazine Aspruzyo An increased risk of QT interval prolongation Details Chloroquine Remdesivir Reduced antiviral activity of remdesivir Details Chloroquine Repaglinide Prandin® Hypoglycemia Details Chloroquine Revumenib Revuforj An increased risk of QT interval prolongation Details Chloroquine Ribociclib Kisqali An increased risk of QT interval prolongation Details Chloroquine Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Risperidone Perseris An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Ritonavir Norvir Increased risk of QT-interval prolongation Details Chloroquine Rosiglitazone Avandia® Hypoglycemia Details Chloroquine Saxagliptin Onglyza Hypoglycemia Details Chloroquine Selpercatinib Retevmo Increased risk of QT interval prolongation Details Chloroquine Semaglutide Ozempic Hypoglycemia Details Chloroquine Sematilide Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Sertindole An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Sevoflurane Petrem Increased risk of QT interval prolongation Details Chloroquine Siponimod Mayzent An increased risk of QT interval prolongation Details Chloroquine Sitagliptin Brynovin Hypoglycemia Details Chloroquine Sodium Phosphate OsmoPrep An increased risk of QT interval prolongation Details Chloroquine Sodium Phosphate, Dibasic An increased risk of QT interval prolongation Details Chloroquine Sodium Phosphate, Monobasic An increased risk of QT interval prolongation Details Chloroquine Solifenacin Vesicare An increased risk of QT interval prolongation Details Chloroquine Sorafenib Nexavar An increased risk of QT interval prolongation Details Chloroquine Sotalol Betapace An increased risk of QT interval prolongation Details Chloroquine Spiramycin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Sulfamethoxazole Sustain Increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Sulpiride An increased risk of QT interval prolongation Details Chloroquine Sultopride An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Sunitinib Sutent An increased risk of QT interval prolongation Details Chloroquine Tacrolimus Astagraf An increased risk of QT interval prolongation Details Chloroquine Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Tamoxifen Nolvadex® Increased risk of retinopathy and increased risk of QT-interval prolongation Details Chloroquine Tedisamil Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Telaprevir Increased risk of QT-interval prolongation Details Chloroquine Telavancin Vibativ Increased risk of QT-interval prolongation Details Chloroquine Telithromycin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Tetrabenazine Xenazine An increased risk of QT interval prolongation Details Chloroquine Tolazamide Tolinase® Hypoglycemia Details

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