Chloroquine

332 interactions 586 cited references
Also sold as: Aralen®
About Chloroquine

An antimalarial and amebicide drug used to prevent and treat malaria and amebiasis. Read the full Chloroquine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Pimozide Saquinavir Levomethadyl Mesoridazine Levoketoconazole
14 Contraindicated 294 Major 23 Moderate 1 Minor
All (332) Contraindicated (14) Major (294) Moderate (23) Minor (1)

Major

Chloroquine Tolbutamide Orinase® Hypoglycemia Details Chloroquine Toremifene Fareston An increased risk of QT interval prolongation, ventricular tachycardia or an increased risk of torsade de pointes Details Chloroquine Tramadol ConZip Increased traMADol exposure, reduced exposure of the active metabolite and an increased risk of seizure Details Chloroquine Trazodone Raldesy An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Chloroquine Triclabendazole Egaten An increased risk of QT interval prolongation Details Chloroquine Trifluoperazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Trimethoprim Primsol Increased chloroquine exposure and increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Trimipramine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Triptorelin Increased risk of QT interval prolongation Details Chloroquine Vandetanib Caprelsa An increased risk of QT interval prolongation and Torsades de pointes Details Chloroquine Vardenafil Levitra An increased risk of QT interval prolongation Details Chloroquine Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Chloroquine Venlafaxine Increased risk of QT-interval prolongation Details Chloroquine Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Chloroquine Vilanterol Increased risk of QT-interval prolongation Details Chloroquine Vildagliptin Hypoglycemia Details Chloroquine Vinflunine Increased risk of QT-interval prolongation Details Chloroquine Voclosporin Lupkynis An increased risk of QT interval prolongation Details Chloroquine Voriconazole Vfend An increased risk of QT interval prolongation Details Chloroquine Vorinostat Zolinza Increased risk of QT-interval prolongation Details Chloroquine Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Chloroquine Zolmitriptan Zomig An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Zotepine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Zuclopenthixol An increased risk of QT interval prolongation Details Chloroquine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Chloroquine Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Dulaglutide Injection Trulicity Hypoglycemia Details Chloroquine Eribulin Injection Halaven Increased risk of QT-interval prolongation Details Chloroquine Exenatide Injection Bydureon Hypoglycemia Details Chloroquine Famotidine Injection Calmicid Increased risk of QT-interval prolongation Details Chloroquine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloroquine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Chloroquine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Chloroquine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Chloroquine Granisetron Injection Granisol An increased risk of QT interval prolongation Details Chloroquine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Chloroquine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Chloroquine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia Details Chloroquine Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia Details Chloroquine Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.