Ciprofloxacin

162 interactions 10 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Brexpiprazole Famotidine Metformin Galantamine Ifosfamide Injection Oxaliplatin Injection

133 Major 29 Moderate

All (162) Major (133) Moderate (29)

Major

Ciprofloxacin Delafloxacin Injection Baxdela An increased risk of fluoroquinolones-related adverse reactions and an increased risk of seizures Details Ciprofloxacin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Ciprofloxacin Dexamethasone Injection Decadron An increased risk of tendon rupture Details Ciprofloxacin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) An increased risk of tendon rupture Details Ciprofloxacin Didanosine Videx® Reduced ciprofloxacin exposure Details Ciprofloxacin Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ciprofloxacin Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ciprofloxacin Disopyramide Norpace An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Dofetilide Tikosyn An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Dolasetron Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Dolasetron Injection Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Ciprofloxacin Dulaglutide Injection Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Elacestrant Orserdu Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Ciprofloxacin Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Encorafenib Braftovi Increased encorafenib exposure, an increased risk of encorafenib-related adverse reactions and an increased risk of QT interval pr... Details Ciprofloxacin Entrectinib Rozlytrek Increased entrectinib exposure, an increased frequency or severity of adverse reactions including increased risk of cardiac arrhyt... Details Ciprofloxacin Eribulin Injection Halaven An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Erlotinib Tarceva Increased erlotinib exposure and risk of toxicity Details Ciprofloxacin Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Famotidine Calmicid An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Famotidine Injection Calmicid An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Felbamate Felbatol An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Ciprofloxacin Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ciprofloxacin Flecainide Tambocor® An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Fludrocortisone Acetate Florinef® An increased risk of tendon rupture Details Ciprofloxacin Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Ciprofloxacin Fostemsavir Rukobia Increased risk of torsade de pointes Details Ciprofloxacin Galantamine Razadyne An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Gatifloxacin Ophthalmic Zymar® An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ciprofloxacin Gemifloxacin Factive An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ciprofloxacin Glasdegib Daurismo Increased risk of QT interval prolongation Details Ciprofloxacin Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Ciprofloxacin Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Granisetron Injection Granisol An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Histrelin Implant Supprelin Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.