Ciprofloxacin
162 interactions 10 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Brexpiprazole
Famotidine
Metformin
Galantamine
Ifosfamide Injection
Oxaliplatin Injection
Major
Ciprofloxacin Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Ciprofloxacin Hydrocortisone Injection A-Hydrocort® An increased risk of tendon rupture Details Ciprofloxacin Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Ciprofloxacin Ibrutinib Imbruvica Increased ibrutinib exposure Details Ciprofloxacin Ifosfamide Injection Ifex Decreased ifosfamide effectiveness Details Ciprofloxacin Infigratinib Truseltiq Increased infigratinib plasma concentrations Details Ciprofloxacin Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Ciprofloxacin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Insulin Detemir (Rdna Origin) Injection Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Insulin Glulisine (Rdna Origin) Injection Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Ivabradine Corlanor An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Ciprofloxacin Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and an increased risk of QT interval prolon... Details Ciprofloxacin Leflunomide Arava Increased exposure of OAT3 substrate Details Ciprofloxacin Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Ciprofloxacin Levofloxacin Levaquin Increased risk of QT interval prolongation Details Ciprofloxacin Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Ciprofloxacin Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Liraglutide Injection Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Lixisenatide Injection Adlyxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Ciprofloxacin Loperamide Diamode Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Ciprofloxacin Lumateperone Caplyta Increased lumateperone exposure, an increased risk of lumateperone-related adverse events and an increased risk of QT interval pro... Details Ciprofloxacin Lurasidone Latuda Increased lurasidone exposure and an increased risk of QT interval prolongation Details Ciprofloxacin Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Ciprofloxacin Mefloquine Lariam® An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Ciprofloxacin Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ciprofloxacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ciprofloxacin Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Ciprofloxacin Metronidazole Flagyl An increased risk of QT interval prolongation Details Ciprofloxacin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Ciprofloxacin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Ciprofloxacin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Ciprofloxacin Mexiletine Mexitil® Increased CYP1A2 substrate exposure and an increased risk of CYP1A2 substrate-related adverse reactions Details Ciprofloxacin Midazolam Nasal Spray Nayzilam Increased midazolam exposure and increased risk for prolonged sedation Details Ciprofloxacin Midazolam Injection Nayzilam Increased midazolam exposure and increased risk for prolonged sedation Details Ciprofloxacin Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Mitapivat Aqvesme Increased mitapivat exposure Details Ciprofloxacin Moxifloxacin Avelox Increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.