Ciprofloxacin

162 interactions 10 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Brexpiprazole Famotidine Metformin Galantamine Ifosfamide Injection Oxaliplatin Injection

133 Major 29 Moderate

All (162) Major (133) Moderate (29)

Major

Ciprofloxacin Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Ciprofloxacin Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Ciprofloxacin Naloxegol Movantik Increased naloxegol exposure Details Ciprofloxacin Nateglinide Starlix® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ciprofloxacin Nifedipine Adalat® Increased NIFEdipine exposure Details Ciprofloxacin Octreotide Bynfezia An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Octreotide Injection Bynfezia An increased risk of QT interval prolongation and torsade de pointes Details Ciprofloxacin Ofloxacin Floxin® An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ciprofloxacin Ofloxacin Ophthalmic Ocuflox An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ciprofloxacin Ofloxacin Otic Floxin® Otic An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ciprofloxacin Olaparib Lynparza Increased olaparib exposure Details Ciprofloxacin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Ciprofloxacin Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Moderate

Ciprofloxacin Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Ciprofloxacin Aspirin Acuprin® An increased risk of convulsions Details Ciprofloxacin Aspirin Rectal Aspirin An increased risk of convulsions Details Ciprofloxacin Avanafil Stendra Increased avanafil exposure Details Ciprofloxacin Bromfenac Ophthalmic Bromday® An increased risk of convulsions Details Ciprofloxacin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of convulsions Details Ciprofloxacin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of convulsions Details Ciprofloxacin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of convulsions Details Ciprofloxacin Diclofenac Transdermal Patch Flector An increased risk of convulsions Details Ciprofloxacin Dutasteride Avodart Increase in dutasteride plasma concentrations Details Ciprofloxacin Etodolac Lodine An increased risk of convulsions Details Ciprofloxacin Fenoprofen Fenopron An increased risk of convulsions Details Ciprofloxacin Flurbiprofen Ansaid An increased risk of convulsions Details Ciprofloxacin Flurbiprofen Ophthalmic Ocufen An increased risk of convulsions Details Ciprofloxacin Ibuprofen Addaprin An increased risk of convulsions Details Ciprofloxacin Ketoprofen Actron® An increased risk of convulsions Details Ciprofloxacin Ketorolac Acular An increased risk of convulsions Details Ciprofloxacin Ketorolac Injection Acular An increased risk of convulsions Details Ciprofloxacin Ketorolac Nasal Spray Sprix An increased risk of convulsions Details Ciprofloxacin Ketorolac Ophthalmic Acular An increased risk of convulsions Details Ciprofloxacin Lanthanum Fosrenol® Reduced bioavailability of quinolone antibiotics Details Ciprofloxacin Levothyroxine Ermeza Decreased efficacy of levothyroxine Details Ciprofloxacin Meclofenamate Meclodium® An increased risk of convulsions Details Ciprofloxacin Mefenamic Acid Ponstel® An increased risk of convulsions Details Ciprofloxacin Meloxicam Alloxate An increased risk of convulsions Details Ciprofloxacin Meloxicam Injection Alloxate An increased risk of convulsions Details Ciprofloxacin Nabumetone Relafen An increased risk of convulsions Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.